San Francisco 49ers running back Isaac Guerendo is unlikely to play in Sunday's game against the host Miami Dolphins, ESPN reported Thursday.
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The San Francisco 49ers can't seem to catch a break.
San Francisco 49ers running back Christian McCaffrey and top backup Jordan Mason are being placed on injured reserve.
Bills Terrel Bernard tackles 49ers Christian McCaffrey during first half action of their home game against the San Francisco 49ers in Orchard …
Josh Allen became the first quarterback since 1970 to score a rushing touchdown, pass for a touchdown and have a scoring reception in the same…
Dec 1, 2024; Orchard Park, New York, USA; San Francisco 49ers running back Christian McCaffrey (23) tries to avoid Buffalo Bills safety Damar …
San Francisco 49ers star running back Christian McCaffrey departed Sunday night's snow game against the Buffalo Bills early in the second quar…
Dec 1, 2024; Orchard Park, New York, USA; San Francisco 49ers running back Christian McCaffrey (23) tries to avoid Buffalo Bills safety Damar …
The Buffalo Bills can clinch the AFC East on Sunday night when they battle the injury-decimated San Francisco 49ers at Orchard Park, N.Y.
Nov 24, 2024; Green Bay, Wisconsin, USA; San Francisco 49ers running back Christian McCaffrey (23) is tackled by Green Bay Packers linebacker …